Synthesis, transport and metabolism of serotonin formed from exogenously
نویسندگان
چکیده
Synthesis, transport and metabolism of serotonin formed from exogenously 2 applied 5-HTP after spinal cord injury in rats. 3 Yaqing Li, Lisa Li, Marilee J. Stephens, Dwight Zenner, Katherine C. Murray, Ian Winship, 4 Romana Vavrek, Glen B. Baker, Karim Fouad and David J. Bennett 5 Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada 6 7 8 Running Title: AADC after spinal cord injury. 9
منابع مشابه
Review of Metabolism, Transport and Role of Serotonin in the Body and the Relation between Serotonin and Diseases
Serotonin (5-hydroxytriptamine), one of the most important neurotransmitters, is synthesized from amino acid L-tryptophan in some neurons located in the central nervous system and intestine enterochromaffin cells . The role of this neurotransmitter is important and involves control of sexual behaviors, morality, sleep, pain, appetite, aggression, cardiovascular function and regulation of gut fu...
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Spinal cord transection leads to elimination of brain stem-derived monoamine fibers that normally synthesize most of the monoamines in the spinal cord, including serotonin (5-hydroxytryptamine, 5-HT) synthesized from tryptophan by enzymes tryptophan hydroxylase (TPH, synthesizing 5-hydroxytryptophan, 5-HTP) and aromatic l-amino acid decarboxylase (AADC, synthesizing 5-HT from 5-HTP). Here we ex...
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